Scientist, Proteomics Jobs

Position: Scientist, Proteomics

Reporting to: Manager, Proteomics

Employment term: Permanent Full-time

Start date: Immediate

Location: Mississauga, ON

About Dalriada Drug Discovery Inc.:

Founded in 2017, Dalriada is a leading Canadian drug discovery organization specialized in small molecule therapies. Purposely built as an agile, co-located and uniquely integrated drug discovery partner, Dalriada accelerates the discovery and development journey of high value new small molecule therapeutics from concept to IND.

Our unique Turn-Key™ operational model offers the global biotechnology industry a full suite of drug discovery, preclinical development, intellectual property, and business expertise to manage and execute tailored R&D programs. To date Dalriada has supported integrated programs of public and venture capital-backed biotech companies, including Antibe, Janpix, Canopy Growth, Oxford Cannabinoid Technologies, atai Life Sciences, and Dunad Therapeutics.

Why join?

Our team of passionate and skilled drug discovery scientists is a key factor in Dalriada’s rapid success. Since inception, the company has prioritized creating an environment that promotes professional, scientific, and personal growth and fosters agile innovation through integrative and interdisciplinary learning across all key drug discovery disciplines. We pride ourselves on providing individuals a unique opportunity in small molecule R&D in Ontario to:

• Make the most direct impact and contribute intellectually to the creation of better medicines. Our scientists design and evaluate new drug molecules across multiple therapeutic areas and are named inventors or direct contributors on patents.
• Be at the forefront with Ontario’s largest and one of Canada’s fastest-growing drug discovery organizations.
• Directly interact with management teams of innovative clinical-stage pharmaceutical and VC-backed biotech companies from across Canada, US and Europe.
• Collaborate with Dalriada’s expert interdisciplinary drug discovery scientists in medicinal & computational chemistry, cell & molecular biology, biophysics & biochemistry, ADME and proteomics (>70% PhD).
• Learn new things every day in a fast-paced, stimulating, values-based company committed to driving growth, delivering solutions, being accountable and creative.
• Actively conduct and advance cutting-edge science in a state-of-the-art R&D facility.
• Work closely with Dalriada senior leadership and executive team of expert drug discovery scientists, innovators, global pharmaceutical industry executives and entrepreneurs, who collectively have > 145 patents, pharma transactions > $2B, 6 companies founded, >215 years of drug discovery experience, led > 100 drug discovery programs and brought drugs to the clinic and market.

Job Summary

The Proteomics Scientist will conduct and manage experiments, analyze, and interpret data, and communicate findings. They will work collaboratively with teams, troubleshoot technical issues, and guide junior team members. The ideal candidate has a Ph.D. in Biochemistry or Analytical Chemistry, demonstrated proteomics expertise, and experience with sample preparation, LC-MS/MS, and data analysis. Strong analytical skills, project management, and teamwork are required, as well as excellent communication and presentation skills.

Specific Duties & Responsibilities

• Executes discovery and targeted proteomic assays to facilitate compound screening, identify protein targets, elucidate mechanism of action, and support medicinal chemistry efforts.
• Maintains lab notebooks and documents the experimental results in database.
• Uses, maintains, and troubleshoots high-resolution mass spectrometers (Orbitrap and TOF), and nanoLC instruments.
• Trains and supervises junior team members.
• Carefully documents research workflows, data, and protocols.
• Monitors, reviews, and critically interprets published research to support experimental efforts.
• Provides mass spectrometry and proteomics expertise to support Dalriada’s drug discovery programs.
• Prepares data summaries and reports to communicate project status among diverse audiences such as project teams and executive boards.
• Develops and conducts mass spectrometry methods for structural characterization of intact and digested proteins.
• Troubleshoots and develops technical solutions to optimize experiments for robust data output.
• Designs and conducts proteomic experiments (including experimental design, data collection, interpretation, and presentation).

Education & Certifications

• Post-graduate lab experience in drug discovery settings is desirable but not necessary.
• PhD in Analytical Chemistry, Biochemistry, Chemical Biology, or related discipline.

Requirements

• Proficiency with open-source and vendor-specific proteomic software (e.g., PEAKS, Proteome Discoverer, MaxQuant, MS Fragger, Progenesis, etc.).
• Superior communication skills (written and verbal) and interpersonal skills.
• Working knowledge of statistics and experience in a scripting language (e.g., R, Python).
• Fast learner, flexible, and innovative, able to work collaboratively within cross-functional teams.
• Driven by scientific excellence and cost/process efficiency.
• Ability to analyze, interpret, and present scientific data, and propose next steps in experimental design and project strategy.
• Approaches work with an entrepreneurial mindset, working independently and seeking professional input when necessary.
• Offers timely results through sound judgment and scientific knowledge.
• Able to manage multiple projects simultaneously and meet aggressive project timelines.
• Experience in both discovery proteomics (label-free, DIA, SILAC, TMT) and targeted proteomics (SRM, PRM).
• Proficiency in proteomics sample preparation techniques (proteolytic digestion, pull-down methods, solid-phase extraction, probe labeling, etc.).
• Expertise in operating orbitrap and TOF mass spectrometers.
• Knowledge of covalent drugs and covalent proteomics.
• Thinks critically and generates creative solutions to challenging scientific questions.
• Deep knowledge and proven experience in proteomics and protein biochemistry across various therapeutic areas.
• Proficiency in relevant programs for data analysis and visualization, such as GraphPad Prism, Microsoft Excel, Microsoft PowerPoint, and Microsoft Word.

If you are interested in this opportunity, please submit your resume to [email protected] referencing Scientist, Proteomics in the subject line.

This position is open to applicants legally authorized to work in Canada.

Dalriada Drug Discovery Inc. is an equal opportunity employer, and we are committed to achieving accessibility by providing accommodation for people with disabilities during our hiring process. Accommodation is available on request for qualified candidates during the recruitment process.

All employment is conditional upon completing and obtaining a satisfactory background check which may include educational, employment, references, and criminal records.