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Associate Scientist, Discovery, Toronto
Company | POINT Biopharma |
Address | Toronto, Ontario, Canada |
Employment type | FULL_TIME |
Salary | |
Category | Technology, Information and Internet |
Expires | 2023-09-07 |
Posted at | 9 months ago |
POINT Biopharma Global Inc. is a globally focused radiopharmaceutical company building a platform for the clinical development and commercialization of radioligands that fight cancer. POINT aims to transform precision oncology by combining a portfolio of targeted radioligand assets, a seasoned management team, an industry-leading pipeline, in-house manufacturing capabilities, and secured supply for medical isotopes including actinium-225 and lutetium-177. POINT’s active clinical trials include FRONTIER, a phase 1 trial for PNT2004, a pan-cancer program targeting fibroblast activation protein-α (FAP-α), and SPLASH, the phase 3 trial for PNT2002 for people with metastatic castration resistant prostate cancer (mCRPC) after second-line hormonal treatment.
- Design, optimize and perform in vitro assays to assess the binding kinetics, affinity, biochemical stability and cellular activity of small molecule and peptide-based ligands
- Support preclinical and late-stage assets as necessary
- In conjunction with managers, establish priorities and meet timelines for key experiments.
- Critically assess data and methods, adapting and adjusting procedures as necessary
- Work collaboratively with R&D staff to execute day-to-day discovery activities
- Oversee the characterization of early-stage ligands using biochemical and/or biophysical techniques, such as enzyme kinetics, SPR, BLI, ELISA, DSF and ITC
- Plan and perform research work both independently and with the guidance of senior scientists.
- Maintaining a safe working environment for themselves and others through full compliance with health and safety protocols.
- Provide clear communication of scientific data to co-workers through internal presentations and written methods.
- Produce high-quality analytical and biochemical data.
- Manage time effectively between multiple projects.
- Perform or direct routine laboratory procedures (generation of common reagents and stocks, maintenance of laboratory equipment, maintaining a clean laboratory environment, etc.)
- Meet deadlines for collaborative projects and internal programs.
- Maintain accurate records of experimental details, SOPs, materials on hand, etc
- Excellent written and verbal scientific communication skills
- Experience with small-molecule and peptide analytical techniques (HPLC, LC/MS, NMR) is an asset
- Familiarity with protein biochemistry, expression, purification and characterization (FPLC, MALLS, western blots)
- Experience with biorthogonal chemistry and protein conjugation (azide-alkyne click chemistry, NHS coupling, cysteine/maleimide chemistry)
- Knowledge or experience with radiopharmaceuticals is considered an asset
- Excellent problem-solving and decision-making skills
- Strong background in developing, performing, and analyzing in vitro biochemical/biophysical assays
- Understanding of drug properties and in vivo behaviour (PK/PD, biodistribution, and principles of medicinal chemistry)
- Experience with typical biochemistry laboratory operations and equipment (pipetting devices, balances, pH meters, centrifuges, plate readers, gel electrophoresis system, gel imagers, etc.)
- 3+ years relevant experience (industry preferred) with M.Sc., 1-2 years experience with Ph.D
- Working knowledge of MS-Office, Graphpad Prism, and ChemDraw
- M.Sc. or Ph.D. in chemistry, biochemistry, chemical biology, pharmacy, or related discipline
- You will help establish and define an organization that will change the course of cancer therapies. and help thousands of people each year
- You will be provided the opportunity to participate in the financial value creation that occurs as POINT grows and becomes a mature pharmaceutical company
- Most importantly, you will spend everyday working on something important
- You will be challenged, and are expected to challenge us, as part of a results-oriented, high performance team, where everyone leaves their egos at the door and lets the best ideas win
- Paid Time Off (Vacation, Personal Days, Sick Days & Public Holidays)
- $500 fitness reimbursement
- RRSP matching plan
- Life insurance
- Eligible for annual incentive bonus plan and stock options
- $50 cell phone reimbursement per paycheck ($1,300 per year)
- Healthcare plan (medical, dental, vision) – effective day 1
- Disability
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